Platelet Aggregation & Adhesion

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Visualization of cellular processes in real-time provides invaluable insight into cell biology. Cell adhesion through protein-protein or protein-carbohydrate interactions plays an important role indirecting cell migration, gene expression, cell growth, morphological changes during development, and programmed cell death.

The BioFlux system is particularly adaptable to platelet adhesion & aggregation screens and can be performed under physiologically-relevant shear flow conditions. With this system, platelet rolling, platelet adhesion, platelet aggregation, and adhesion inhibition can be quantitated under continuous flow, providing major work flow advantages over traditional adhesion assays.

platlet adhesion
Functionalized BioFlux flow channels were used to analyze the effect of guanosine on platelet adhesion and aggregation, mimicking arterial flow conditions. Guanosine was shown to inhibit platelet aggregation (Palomo et al., 2013).

Key BioFlux Advantages For Platelet Aggregation & Adhesion Studies

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Calcein AM Labeled Platelet Aggregation on Type I collagen

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Whole blood labeled with calcein AM flowing over collagen 1 at 40 dyn over 5 minutes.