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CHRFAM7A diversifies human immune adaption through Ca2 signalling and actin cytoskeleton reorganization
publications

CHRFAM7A diversifies human immune adaption through Ca2+ signalling and actin cytoskeleton reorganization

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Commonly Used Therapeutics Associated with Changes in Arousal Inhibit GABAAR Activation
publications

Commonly Used Therapeutics Associated with Changes in Arousal Inhibit GABAAR Activation

Abstract: GABAA receptor-positive modulators are well-known to induce sedation, sleep, and general anesthesia. Conversely, GABAA receptor negative allosteric modulators (GABAARNAMs) can increase arousal and induce...

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Lowering Excitotoxity and Stabilizing Serial Activation in NMDA
publications

Lowering Excitotoxity and Stabilizing Serial Activation in NMDA

 

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Conformational transitions and allosteric modulation in a heteromeric glycine receptor
publications

Conformational transitions and allosteric modulation in a heteromeric glycine receptor

 

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IonFlux A Microfluidic Patch Clamp System Evaluated with Human Ether a gogo Related Gene Channel Physiology and Pharmacology
publications

IonFlux: A Microfluidic Patch Clamp System Evaluated with Human Ether-à-gogo Related Gene Channel Physiology and Pharmacology

Ion channel assays are essential in drug discovery, not only for identifying promising new clinical compounds, but also for minimizing the likelihood of potential side...

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Nebivolol as a Potent TRPM8 Channel Blocker A Drug Screening Approach through Automated Patch Clamping and Ligand Based Virtual Screening
publications

Nebivolol as a Potent TRPM8 Channel Blocker: A Drug-Screening Approach through Automated Patch Clamping and Ligand-Based Virtual Screening

Transient Receptor Potential Melastatin 8 (TRPM8) from the melastatin TRP channel subfamily is a non-selective Ca2+-permeable ion channel with multimodal gating which can be activated...

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Electrical Characterization of the Short and Long Gamma Subunit Splice Variants of Human GABAA Receptors
publications

Electrical Characterization of the Short and Long Gamma Subunit Splice Variants of Human GABAA Receptors

 

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Characterization of Compound Specific Concentration Independent Biophysical Properties of Sodium Channel Inhibitor Mechanism of Action Using Automated Patch Clamp Electrophysiology
publications

Characterization of Compound-Specific, Concentration-Independent Biophysical Properties of Sodium Channel Inhibitor Mechanism of Action Using Automated Patch-Clamp Electrophysiology

 

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An advanced automated patch clamp protocol design to investigate drug – ion channel binding dynamics
publications

An advanced automated patch clamp protocol design to investigate drug – ion channel binding dynamics

 

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