RaftNotes describe applications and protocols for use with the CellRaft ^® Technology

Functional genomic analysis provides a connection between cellular phenotypes, such as drug responsiveness, and their underlying genomic precursors, such as sequence variation or differential gene expression.

Single cell genomic analysis has already impacted a range of life science fields, including tumor clonality, neuronal mosaicism, and drug resistance mechanisms. The CellRaft Technology uniquely enables the sorting and isolation of single nuclei for downstream analysis. Here we provide optimal methods for imaging nuclei on CellRaft Arrays, and downstream molecular biology protocols for the amplification and preparation of nucleic acid prior to sequencing.