Physiological shear
Definition
Flow conditions intended to resemble those in vivo (e.g., vasculature, catheters, mucosal surfaces).
Why it matters
For scientific teams:
- Improves relevance of in vitro models.
- Enables accurate study of normal cellular behavior.
- Supports mechanotransduction research.
For decision-makers:
- Increases translational confidence.
- Reduces gap between in vitro and in vivo results.
- Strengthens disease modeling workflows.
FAQ
Q: Why model physiological shear?
A: Cell behavior depends on realistic mechanical forces.
Q: How is it implemented?
A: By targeting shear stress ranges seen in vivo.