BioFlux Applications

Cellular Analysis, Research, and Imaging

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Physiological flow has a profound impact on many biological processes, such as thrombus formation, cell adhesion, and endothelial cell permeability.

BioFlux Shear Flow Systems give you the ability to mimic physiological flow in your research and drug discovery experiments to reveal the true biology.

Check the application pages to see how BioFlux can accelerate your live cell assays.

“Given the critical role of shear in regulating platelet adhesion and thrombus growth, these findings may have potential pathophysiological significance.” [Jackson, et al., 2006]

Cell Biology Applications

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Atherosclerosis

Examine atherosclerosis using primary plaques or cell co-culture models
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Chemotaxis & Invasion

Visualize and track cell movement across and through monolayers
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Vascular Biology

Image properly aligned endothelial cells, examine cell permeability, and more
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Stem Cells

Investigate stem cell function under flow: homing, adhesion, transmigration, and differentiation

Immunology Applications

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Cell Adhesion & Rolling

Visualize and quantify the leukocyte adhesion cascade over time using time-lapse microscopy
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Transmigration

Examine cell migration through tissue
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Chemotaxis

Quickly assay and analyze cellular movement in response to chemical stimuli in a physiological environment

Hematology Applications

Platelet aggregation and adhesion

Platelet Aggregation & Adhesion

Study the mechanisms of thrombus formation and treatment strategies under biological flow
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Sickle Cell Disease

Investigate adhesive properties of sickle erythrocytes in a biological blood flow environment
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COVID-19 Research

Study causes and treatments of thrombosis in COVID-19 patients

Oncology Research Applications

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Tumor Microenvironment

Control and manipulate the tumor microenvironment and test potential treatments
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Cancer Cell Migration & Invasion

Create two adjacent micro-environments to analyze cell migration and invasion.
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Circulating Tumor Cells

Analyze CTC adhesion and clustering under shear flow
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Consumables

BioFlux Plates
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Operation

Bioflux Software
BF100 Stage

Upgrades

Bioflux Upgrades
Ion Channels

Lab Services

BioFlux Lab Services
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Customer Spotlight

Modeling of Catheter-Associated Infection

BioFlux was used in a recent study modeling catheter-associated infection by using BioFlux microfluidics to mimick the in vivo conditions of urinary catheters. In their lab, the BioFlux 200 system has been used to evaluate the efficacy of poloxamers in reducing E. coli adhesion under controllable shear forces by exploiting BioFlux silicone microfluidic flow channels, thus mimicking the in vivo conditions of urinary catheters in terms of both flow conditions and catheter material.