Leukocyte Adhesion & Rolling

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Visualization of cellular processes in real-time provides invaluable insight into cell biology. Cell adhesion through protein-protein or protein-carbohydrate interactions plays an important role indirecting cell migration, gene expression, cell growth, morphological changes during development, and programmed cell death.

The BioFlux system is particularly adaptable to cell adhesion & rolling screens and can be performed under physiologically-relevant shear flow conditions. With this system, cell rolling, cell adhesion, and adhesion inhibition can be quantitated under continuous flow, providing major work flow advantages over traditional adhesion assays.

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Functionalized BioFlux flow channels were used to analyze eryptotic erythrocytes adhering to VWF fibers (Nicolay et al., 2018).

Key BioFlux Advantages For Cell Adhesion & Rolling Studies

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Jurkat cells rolling on E-selectin

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Jurkat T cells rolling over E-selectin at 2 dyn.