Leukocyte Adhesion & Rolling

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Visualization of cellular processes in real-time provides invaluable insight into cell biology. Cell adhesion through protein-protein or protein-carbohydrate interactions plays an important role indirecting cell migration, gene expression, cell growth, morphological changes during development, and programmed cell death.

The BioFlux system is particularly adaptable to cell adhesion & rolling screens and can be performed under physiologically-relevant shear flow conditions. With this system, cell rolling, cell adhesion, and adhesion inhibition can be quantitated under continuous flow, providing major work flow advantages over traditional adhesion assays.

Functionalized BioFlux flow channels were used to analyze eryptotic erythrocytes adhering to VWF fibers (Nicolay et al., 2018).

Key BioFlux Advantages For Cell Adhesion & Rolling Studies

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Jurkat cells rolling on E-selectin

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Jurkat T cells rolling over E-selectin at 2 dyn.