In vivo, most cell types exist surrounded by moving fluid that influences their phenotype and function. The flow created from moving fluids creates shear stress, which can influence cytokine production, polarization, transcription factor expression, organization, and morphology of many cell types (Tzima, E., 2005, Shi, X., 2016, Chen, C., 2014). However, despite these facts, many […]
Single cell workflows are hot topics in scientific research today. The ability to turn a single cell into a viable monoclonal colony is essential for cell line development, recombinant protein, and antibody production, and induced pluripotent stem cell engineering. Such monoclonal cell lines are the foundational building blocks enabling cutting-edge disease modeling, drug screening, and […]
IPSCs and organoids offer a powerful platform for modeling disease & drug discovery. These models can deliver accurate insights which cannot be provided by immortalized cell lines or primary cells and are not subject to limitations of animal models. Notable disease models have been developed for cystic fibrosis, Alzheimer’s disease, and cancer. The focus of […]
