Looking for more information about our CellRaft AIR® System or CellRaft® Arrays?
Download the following brochures.
CellRaft AIR® System
The CellRaft AIR System enables workflows to image, identify, and isolate viable single cells or clonal colonies.
Download our CellRaft AIR System brochure to learn more.
CRISPR & Cell Line Development
The CellRaft AIR System is a fully automated and hands-free imaging and isolation solution for limiting manual screening and cell manipulation efforts.Â
Download our CRISPR & Cell Line Development application flyer to learn more.
Genomics
Eliminate doublets and debris by automated selection of the best single cells that maintain their native phenotype for downstream genomic analysis.Â
Download the Genomics application brochure to get more information.
Organoids
The CellRaft Technology with 3D capabilities offers a solution with a fully automated imaging, analysis, and isolation workfl ow for organoid culture.
Download our Organoid application brochure to learn more.
Stem Cells
The CellRaft AIR System’s Stem Cell Workflow can eliminate expensive additives and provide greater yields to accelerate the path to drug discovery and new therapies.Â
Download our Stem Cell application brochure to learn more.
CORE Labs
Accelerate your research by collapsing labor-intensive workflows onto the automated CellRaft AIR system.
Download the CellRaft AIR System for CORE Labs brochure to get more information.
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CROs
Tracking and traceability is critical for CROs. Using brightfield microscopy, the CellRaft AIR System identifies single cells and serially images over time to capture complete growth records of clonal development.
Download our CellRaft AIR System brochure to learn more.Â
RaftNotes
RaftNotes are publications specifically for AIR System users that features application updates and product notes.
Making the Impossible Possible: Platform and Protocols to Develop Clonal iPSC Derived Organoids
In the last decade, several protocols and commercial kits have been launched to help differentiate iPSCs into multicellular, neuronal organoids that closely resemble human brain development, including region-specific cellular composition and functional physiology. However, the adoption of these organoid models is still limited to relatively low throughout applications, as the workflows are hampered by challenges in reproducibility and scalability, as well as being manually intensive. Here we report the use of the CellRaft® Technology, to develop and enable streamlined, reproducible organoid workflows that offer reliable imaging, software-guided selection, and automated isolation of single organoids for downstream applications.
Taking the fear out of iPS cell line development
Despite significant strides in technology and increased access for researchers, iPSC culture remains a challenge, thereby limiting its widespread utility for therapeutic and research use. Common pain points include:
1) iPSC lines are sensitive and easily perturbed, requiring constant maintenance.
2) Poor culture conditions and cell line instability can lead to spontaneous differentiation and loss of pluripotency.
3) Generating monoclonal cell lines is incredibly challenging, with low efficiency and lack of proven clonality.
4) The labor, cost, and reagent burden associated with iPSC maintenance and workflows are incredibly high and often prohibitive for the end user.
Download this RaftNote to see how some of these challenges can be overcome.
Image, Identify, and Isolate Single Organoids using the CellRaft AIR® System
The advancement of 3D culture systems has transformed cell-based assays for biological research and drug discovery due to their ability to re-capitulate the structure and cellular complexity of in vivo tissues. Organoids are unique due in their ability to self-organize and closely replicate in vivo pathophysiology. Most laboratory instruments employed to assess endpoints using traditional organoid cultures have limitations that preclude assessment of the heterogeneity within the population or retrieval of single, intact 3D structures for downstream applications.
