Looking for more information about our CellRaft AIR® System or CellRaft® Arrays?
Download the following brochures.
CRISPR & Cell Line Development
The CellRaft AIR System is a fully automated and hands-free imaging and isolation solution for limiting manual screening and cell manipulation efforts.
Eliminate doublets and debris by automated selection of the best single cells that maintain their native phenotype for downstream genomic analysis.
Download the Genomics application brochure to get more information.
The CellRaft AIR System’s Stem Cell Workflow can eliminate expensive additives and provide greater yields to accelerate the path to drug discovery and new therapies.
Download our Stem Cell application brochure to learn more.
Tracking and traceability is critical for CROs. Using brightfield microscopy, the CellRaft AIR System identifies single cells and serially images over time to capture complete growth records of clonal development.
Download our CellRaft AIR System brochure to learn more.
RaftNotes are publications specifically for AIR System users that features application updates and product notes.
Despite significant strides in technology and increased access for researchers, iPSC culture remains a challenge, thereby limiting its widespread utility for therapeutic and research use. Common pain points include:
1) iPSC lines are sensitive and easily perturbed, requiring constant maintenance.
2) Poor culture conditions and cell line instability can lead to spontaneous differentiation and loss of pluripotency.
3) Generating monoclonal cell lines is incredibly challenging, with low efficiency and lack of proven clonality.
4) The labor, cost, and reagent burden associated with iPSC maintenance and workflows are incredibly high and often prohibitive for the end user.
Download this RaftNote to see how some of these challenges can be overcome.
The advancement of 3D culture systems has transformed cell-based assays for biological research and drug discovery due to their ability to re-capitulate the structure and cellular complexity of in vivo tissues. Organoids are unique due in their ability to self-organize and closely replicate in vivo pathophysiology. Most laboratory instruments employed to assess endpoints using traditional organoid cultures have limitations that preclude assessment of the heterogeneity within the population or retrieval of single, intact 3D structures for downstream applications.
The AIR System offers unique advantages over technologies, such as flow cytometry and droplet dispensers, designed to assess cells in suspension. The limitations to other technologies include impacts on cell viability, inability to interrogate small numbers of cells, and reliance on fluorescent markers or staining for cell characterization. To demonstrate the value of the CellRaft technology for use in suspension cell line development, we have established methodologies for attaching suspension cells to the CellRaft Arrays during single cell expansion while still allowing the cells to expand in suspension after the clone of interest has been isolated.