Hyperacute rejection remains a major obstacle in lung xenotransplantation, driven by human antibodies targeting glycan structures on porcine endothelial cells.
In this webinar, Nathalie Roters shares how her team used chemical oxidation with sodium periodate under physiological shearFlow conditions intended to resemble those in vivo (e.g., vasculature, catheters, mucosal surfaces).shear flowFluid movement that applies force to cells and biofilms; used to mimic physiological/pathological conditions. to selectively mask immunogenic glycans like αGal without compromising cell viability.
By blunting antibody recognition (IgG, IgM, IgA), this approach offers a promising path toward making porcine cells less visible to the human immune system.
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