Pre-Recorded Webinar
Abstract:
Nicotinic acetylcholine receptors are a subset of cholinergic receptors that respond to acetylcholine. Target disorders that may be linked to nicotinic ion channels as a potential for drug discovery include muscle dystrophies, myasthenia gravis and myogenic disorders. With integrated solution control and rapid fluid exchange, the IonFlux system is ideally suited to ligand-gated ion channel research. We developed and validated high throughput automated patch clamp assays for nAChR ion channels to profile new chemical entities for drug discovery. These assays are capable of screening much larger libraries than previously feasible by conventional whole cell patch clamp and provide more functional information than fluorometric methods.
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