In this webinar, Dr. Ben Park will present findings from his recent PNAS publication investigating the long-term stability of cancer cells engineered with recurrent SF3B1 hotspot mutations.
The study reveals a surprising tendency for edited cells to revert toward the wild-type genotype over time and demonstrates how longitudinal monitoring of verified monoclonal populations provided new insight into the selective pressures acting on these mutations.
Dr. Park will discuss the experimental approach used to isolate, verify, and follow individual edited clones and the implications of these findings for disease modeling, genome editing, and cancer research.
You’ll Learn:
Play Video
