Microbiology Applications
Antimicrobial Screening, Biofilm Formation, & Host-Pathogen Interactions
Bacteria and fungi organized into biofilms are highly refractory to known antibiotics and biocides. To develop new solutions to combat biofilms, screening technologies must be designed to grow biofilms under conditions that represent an in vivo or in situ community while maintaining the ability to add and observe the effects of compounds.
BioFlux Shear Flow Systems offer a comprehensive solution for running both fundamental biology assays as well as anti-microbial compound screens.
Oral Biofilms
Use saliva as media to replicate oral cavity for biofilmA structured microbial community attached to a surface, typically more tolerant to antibiotics/biocides than planktonic cells. growth
Host-Pathogen Interactions
Form fungal and bacterial biofilms on epithelial monolayers in vitro
Mutant Screens
Use controlled shear flowFluid movement that applies force to cells and biofilms; used to mimic physiological/pathological conditions. on knockout mutant biofilms under physiologically relevant conditions
Medical Device Infections
PDMS and custom microfluidic plates mimic medical device infection environment
Antimicrobial Screens
Analyze effectiveness of novel antimicrobials on biofilm growth under shear flow
Adhesion Strength
Quantify biofilm adhesion and measure binding specificity in a microfluidic channel
