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In the formation of biofilms, adherence of microbes to a surface is followed by cell division and/or capture of free-flowing microbes into the growing biofilm and production of an extracellular matrix of macromolecules. In this novel investigation, a BioFlux shear flow system was used to determine the mechanism of fungal catch bonding and biofilm formation under shear flow. Use of a BioFlux enabled the investigators to find that shear stress increased adhesion by activating amyloid formation.