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In this work, CellRaft arrays were used to generate clonally derived cell populations from single cells prior to sequencing, providing a ground-truth reference for benchmarking somatic mutation detection methods. Researchers seeded single-cell suspensions onto CellRaft arrays to isolate individual cells and expand them into clones, which were then subjected to whole-genome sequencing. This approach enabled a direct comparison between single-cell sequencing data and true clonal mutation profiles, allowing the team to quantify technical artifacts and improve the accuracy of somatic mutation calling across single-cell and single-molecule sequencing platforms.