Resources

Publication: Lysophosphatidic acid suppresses apoptosis of high-grade serous ovarian cancer cells by inducing autophagy activity and promotes cell-cycle progression via EGFR-PI3K/Aurora-AThr288-geminin dual signaling pathways

In this study the CERO 3D Incubator & Bioreactor was used to culture A2780 cells and OVCAR5 spheroids in suspension. The researchers showed that LPA can suppress apoptosis of high-grade serous ovarian cancer cells by inducing autophagy activity and promote cell-cycle progression via EGFR-PI3K/Aurora-AThr288-geminin dual signaling pathways. The study provides potential targets for enhancing the clinical benefit of HGSOC precision medicine.

Related Resources

Researchers at Columbia University used the CellRaft AIR System to support the development of precisely engineered human embryonic stem cell (hESC) lines for a study...

In this study, CellRaft AIR was used to isolate, verify, and expand monoclonal cell lines carrying engineered SF3B1 mutations, forming the basis of an isogenic...

In this work, CellRaft arrays were used to generate clonally derived cell populations from single cells prior to sequencing, providing a ground-truth reference for benchmarking...