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Acute kidney injury develops in 5% of hospitalized patients and leads to significant morbidity, mortality, and financial costs. In this investigation, the authors leveraged a BioFlux shear flow system to image and quantify neutrophil adhesion to TNF-α activated HUVECs to simulate ischemia-reperfusion injury. It was found that Slit2 reduced neutrophil infiltration without impairment of their protective functions.