Publications Using the CellRaft™ Technology
See these scientific publications for demonstrations of the various uses for products based on the CellRaft Technology.
The widespread use of lab-on-a-chip devices containing microcavities in the form of microwells, traps, dead ends, and corners, is often precluded by the trapping of air bubbles. Allbritton and colleagues present a straightforward and simple approach to mitigating bubble formation that can be applied to the CytoSort™ Arrays that are the cornerstone of the CellRaft® Technology. Air bubbles are eliminated in a two-step process, whereby microarrays are first hydrophilized by plasma treatment, and subsequently coated with a monosaccharide such as D-glucose or D-sorbitol. Following this treatment, microwell arrays can be stored for as long as 6 months in air, and complete rewetting of the microwells is demonstrated by the dissolution of the monosaccharide with an aqueous solution.
Selection and isolation of single cells from a mixed population is a common procedure, for example, during the development of clonal cell lines that are genetically engineered, derived from stem cells, or grown from patient samples, single cells must be isolated and then cloned to form a homogeneous population. While myriad methods exist, they commonly rely on enzymatic or mechanical release, which imposes drawbacks in terms of loss of cell morphology, removal of cell surface markers, damage to cell membranes, alterations in cellular physiology, and loss of viability. In this seminal work describing the CellRaft® Technology, the authors demonstrate the fabrication of a microwell array that possesses detachable concave elements, termed CellRafts®, using a PDMS mold combined with standard dip-coating procedures. The resulting microarrays have low auto-fluorescence and are easily removable, in a targeted fashion, allowing for isolation and clonal expansion of single cells. Furthermore, the CytoSort™ Arrays allow for the assessment of cells based on morphology in a time-resolved manner and can be tailored to workflows requiring few to hundreds of thousands of cells.
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Cell Microsystems Partners with United BioChannels to Develop Commercial Strategy and Sales Execution
SAN DIEGO, CA and DURHAM, NC – Cell Microsystems, a developer of advanced research tools for single cell workflows, has partnered with United BioChannels (UBC), a leading brand management consultancy, to enhance Cell Microsystems’ marketing and sales capabilities. The agreement enables Cell Microsystems to leverage UBC’s expertise in strategic marketing
Cell Microsystems is pleased to announce the launch of their new website at https://cellmicrosystems.com. The new site offers the ability to shop and order consumables with customer accounts and enables credit card payments. Users of the site can also easily navigate through the latest research and applications, and quickly access
Research Triangle, Durham, NC: Cell Microsystems, a developer of advanced research tools for single cell workflows, is pleased to announce it has entered into a distribution agreement with Bucher Biotec AG. The Swiss distribution company is known to represent some of the most innovative life science research instrumentation from companies